| Imatinib is a small molecule kinase inhibitor. Gleevec film-coated tablets contain imatinib mesylate equivalent to 100 mg or 400 mg of imatinib free base. Imatinib mesylate is designated chemically as 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-phenyl]benzamide methanesulfonate and its structural formula is
Imatinib mesylate is a white to off-white to brownish or yellowish tinged crystalline powder. Its molecular formula is C29H31N7O •CH4SO3 and its molecular weight is 589.7. Imatinib mesylate is soluble in aqueous buffers ≤ pH 5.5 but is very slightly soluble to insoluble in neutral/alkaline aqueous buffers. In non-aqueous solvents, the drug substance is freely soluble to very slightly soluble in dimethyl sulfoxide, methanol and ethanol, but is insoluble in n-octanol, acetone and acetonitrile.
|
2-Dimethylamino-1-(3-pyridyl)-2-propene-1-one |
55314-16-4 |
Imatinib intermediate |
|
2-Methyl-5-nitrophenyl)guanidine nitrate |
152460-08-7 |
Imatinib intermediate |
|
4-[(4-Methyl-1-piperazinyl)methyl]bezoyl acid
Dihydrochloride .1/2H2O |
148077-69-4 |
Imatinib intermediate |
|
4-[(4-Methyl-1-piperazinyl)methyl]benzoyl chloride,
dihydrochloride |
106261-64-7 |
Imatinib intermediate |
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N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-
pyrimidineamine |
152460-09-8 |
Imatinib intermediate |
|
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-
pyrimidineamine |
152460-10-1 |
Imatinib intermediate |
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