| TARCEVA (erlotinib),a kinase inhibitor, is a quinazolinamine with the chemical name N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine. TARCEVA contains erlotinib as the hydrochloride salt that has the following structural formula:
Erlotinib hydrochloride has the molecular formula C22H23N3O4•HCl and a molecular weight of 429.90. The molecule has a pKa of 5.42 at 25°C. Erlotinib hydrochloride is very slightly soluble in water, slightly soluble in methanol and practically insoluble in acetonitrile, acetone, ethyl acetate and hexane.
|
3-Ethynylbenzeamine |
54060-30-9 |
Erlotinib intermediate |
|
4-Chloro-6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazoline |
183377-18-1 |
Erlotinib intermediate |
|
6,7-Bis-(2-methoxyethoxy)-4(3H)-quinazolinone |
179688-29-0 |
Erlotinib intermediate |
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